Cause of gout

To understand the cause of gout, it is essential to know how the formation of uric acid occurs in the body. All the DNA in our body consists of two types of molecules, they are

PurinesAdenineGuaninePyrimidinescytosineguanineuracil

Uric acid is the final product of the end of the metabolism of purines. Uric acid formation depends on two factors

the amount of purines ingested dietthe of purine formation in the body adenine is converted to adenine monophosphate under the effect of the enzyme adenine phospho-ribosyl-pyrophosphate synthetase.Adenine monophosphate is then converted to adenosine under the effect of the enzyme nucleotidase.Adenosine is then converted into Inosine under the effect of the enzyme adenosine deaminase.Inosine is then converted into Hypoxanthine under the effect of the enzyme nucleoside phosphorylase.Hypoxanthine is then converted to Xanthine by xanthine oxidase enzyme.Xanthine is transformed into uric acid still under the effect of the enzyme xanthine oxidase.

The level of uric acid in the body depends on two factors

The rate of formation of uric acid.The rate of excretion of uric acid by the kidneys.

An increase in training or a reduction in uric acid excretion will result in the accumulation of uric acid in blood. When blood levels of uric acid through normal values then this condition is called hyperuricemia. This is the stage of precursor of gout

The normal value of uric acid in the blood of adults is approximately 360 to 415 micro MOL/litre or 6.8 milligrams/deciliter 6. At this level, the blood is saturated with uric acid. When the concentration of uric acid passes through this level then the blood becomes supersaturated solution. Now, formation and precipitation of uric acid crystals can occur at any time.

Precipitation of crystals causes irritation of the synovial membrane of the joint and causes inflammation, pain and swelling.

Factors led to an increase in the formation of uric acid in the body include the following and these represent 10% of the cases of hyperuricemia as a cause of gout

food consumption of the liver, pancreas, kidneys and anchovydiseases that cause an increase in turn and destruction of the cells in the bodyblood cancershemolytic anemia caused by the bite of snake, poisoning, malariadestruction of muscle tissue (rhabdomyolysis) by extreme physical activity or a continuous epilepsy or an attackdeficiency of heart of the activity of the enzyme hypoxanthine-phosphoribosyl-transfraseincreased enzymes phospho-ribosyl-pyrophosphate synthetasepsoriasispagets diseasealcoholismobesity

The factors that cause a reduction in the excretion of uric acid by the kidneys include the following and these represent 90% of cases of hyperuricemia as a cause of gout.

Failure of the toxicityhigh of kidneyslead pressurehypothyroidismeclampsia in pregnancyDown blood syndromesarcoidosisberylliosisDrugs as asaspirinlevodopacyclosporineethambutolpyrizinamidediuretics (increase the formation of urine)

Hyperuricemia sees 2 to 13% of the normal population. The prevalence of gout is between 1.3 tp 3.7%. This means that many people with hyperuricemia develop never drop. If it is detected in routine tests and then the cause of hyperuricemia should be discovered and factors such as hypertension, obesity, alcoholism must be controlled.

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This page was created on November 14, 2008.

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